Reye Syndrome: Symptoms, Causes and Prevention
Reye syndrome is a very rare disorder, causing damage to the brain and liver. Although these syndromes can occur at any age, but the cases are more observed in the children. It is mostly infected those who have recently had a viral infection, such as chicken pox or flu.
Taking aspirin when a viral infection, increases the risk of having Reye syndrome. Chickenpox or flu has a headache for the child, but keep in mind that in such a situation do not give them aspirin.
What are the Symptoms of Reye Syndrome?
The symptoms of Reye syndrome instigate to appear a few days after viral infections such as colds, flu and chickenpox.
Symptoms at the first stage may include:
- Rashes on the feet and palms of hands.
- Persistent and heavy vomiting.
The symptoms of the second stage:
The symptoms of the third stage:
- Possibility of going into a coma.
- The probability of oedema of the brain.
- Sometimes respiratory arrest.
The symptoms of the fourth stage:
- Severe coma.
- Minimum response to light.
- Liver dysfunction.
Symptoms of the fifth stage include:
- Severe coma.
- Malfunctioning of many body parts.
- Loosening in the body.
- Hyper anaemia.
Cause of Reye Syndrome.
The exact cause has not yet been ascertained, though these can be due to a variety of reasons. It is believed that the use of aspirin during viral infections leads to the onset of this syndrome, especially during flu and chickenpox.
In some cases, it is already present as a metabolic disorder that is exposed to viral infections. In addition, exposure to toxins such as pesticides and paint thinners can also cause this syndrome.
How to Identify Reye Syndrome?
Liver biopsy can help to identify other conditions affecting the liver. (3)
Biopsy of the Skin.
A skin biopsy is required to test fatty acid oxidation disorders or metabolic disorders. (5)
Click here to know Nutrition for Gastro Esophageal Reflux Disease.
How To Treat Reye Syndrome?
Reye syndrome is a serious condition that can be emergency, so it is necessary to have early treatment. There is no cure for Reye syndrome, but an attempt can be made to treat or reduce its symptoms.
For this, the child has to be hospitalized and the doctors must take care of that child’s body, it does not lack water and the balance of electrolytes must be correct. Children who are having seizures due to Reye syndrome are given medicines to control seizures.
A breathing machine or respirator is used to keep the breathing normal in severe cases. The sooner the diagnosis of this syndrome is, the more likely the person is to recover, otherwise it can cause permanent damage to the person’s mind.
Reye syndrome also acknowledged as Reye-Johnson syndrome which is a rare disorder and which can cause severe damage to the liver and brain. If it is not treated immediately, it can lead to permanent brain injury or death.
Reye-Johnson syndrome is a rapidly growing encephalopathy that causes death in 20-40% of affected people and leaves the brain of one-third of those who survive by damage to a significant degree. About 90% of cases in children are associated with the use of aspirin and often their liver is increased. (6)
The rates of this syndrome saw a decrease of more than 90% when the use of aspirin in children was stopped. It affects one or two out of one million children per year. In the world, less than 250-500 cases are registered every year.
How It Affects the Body?
It affects all organs of the body but is most harmful for the brain and liver. It increases brain pressure rapidly and often causes mass clots of fat in the liver or other organs.
How To Prevent and Control Reye Syndrome?
Children with fatty acid oxidation disorder should not give products containing aspirin.
The drugs used in treatment are;
Intravenous Liquid: Glucose and electrolyte can be provided through IV tube. (7)
Diuretics: It can be used to reduce intra-cranial pressure and increase the loss of liquid by urination. (8)
Mannitol: It is a drug to help in brain inflammation. (9)
What are the Exercises for a Person with Reye Syndrome?
Reye Syndrome and Pregnancy.
Low aspirin is considered safe to use daily in pregnancy, which is less likely to cause problems in the mother or child.
Low dose aspirin prophylaxis should be reviewed for women who have several moderate risk factors for preeclampsia.
Frequently Asked Questions.
1. Does Pepto Bismol cause Reye syndrome?
Yes, according to the several studies it is found that Pepto-Bismol can cause Reye syndrome. However, it is not limited to Pepto-Bismol, other studies proved that, this syndrome are also connected with the use of aspirin.
2. Can Advil cause Reye syndrome?
Yes, you can use ibuprofen for relief from symptoms in children under 18 years of age. Examples of ibuprofen include Advil and Motrin. Do not use products containing ibuprofen in children under 6 months of age without the consultation of the doctor.
3. Can adult gets Reye syndrome?
Yes, this syndrome was also diagnosed in the seven adults with the age of 18 to 46 years old. It is more difficult to diagnose in adults and can suspected in patients with symptoms of unexplained altered behavior with viral illness and vomiting. Liver biopsy is usually mandatory for the adults.
Brain Damage can also cause death if Reye syndrome is not treated. Therefore, it is necessary to consult a doctor immediately based on the symptoms.
1. Reye’s syndrome;
2. Reye’s syndrome;
3. Agostino Pugliese, Tiziana Beltramo and Donato Torre; 18 August 2008 ; Reye’s and Reye’s‐like syndromes; Retrieved from
4. Reye’s syndrome;